- Working with InhibOx
The InhibOx Applications Team has at its disposal a complete array of technologies to drive structure-, ligand- and fragment-based design approaches, often used in combination to identify diverse sets of novel lead candidates.
Whatever your starting point: a failed HTS, sub-optimal or IP constrained existing in-house leads, or literature data on a few (maybe only one) known ligands, InhibOx can apply approaches from its CADD Array that will assist in identifying novel chemical scaffolds and advancing your project. The choice of which combination of technologies to apply - from shape, fragment, property, or pharmacophore approaches - will be driven by the starting information and your goals.
When you have data on the structure of your macromolecular target, we have the technology, know-how, and computational resources to investigate thoroughly the bioinformatics landscape, including the conformation flexibility of your target and issues related to target selectivity. The aim is to provide the highest quality analysis and the greatest diversity of novel chemical matter for onward consideration.
Figure 1: DrugFinder Lead – a flexible and robust technology for lead identification